For genomes to stay in shape, insulators must be up to PAR

Cell. 2013 Sep 26;155(1):15-6. doi: 10.1016/j.cell.2013.09.012.


Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Chromosomes, Insect / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / metabolism*
  • Insulator Elements*
  • Poly Adenosine Diphosphate Ribose / metabolism*


  • DNA-Binding Proteins
  • Drosophila Proteins
  • Poly Adenosine Diphosphate Ribose