NR4A orphan nuclear receptors in glucose homeostasis: a minireview

Diabetes Metab. 2013 Dec;39(6):478-84. doi: 10.1016/j.diabet.2013.07.005. Epub 2013 Sep 26.


Type 2 diabetes mellitus is a disorder characterized by insulin resistance and a relative deficit in insulin secretion, both of which result in elevated blood glucose. Understanding the molecular mechanisms underlying the pathophysiology of diabetes could lead to the development of new therapeutic approaches. An ever-growing body of evidence suggests that members of the NR4A family of nuclear receptors could play a pivotal role in glucose homeostasis. This review aims to present and discuss advances so far in the evaluation of the potential role of NR4A in the regulation of glucose homeostasis and the development of type 2 diabetes.

Keywords: Diabetes; Diabète; Facteur de transcription; Glucose; Insulin; Insuline; Metabolism; Métabolisme; NR4A; Nuclear receptor; Récepteur nucléaire; Transcription factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Glucose / metabolism*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Homeostasis
  • Humans
  • Insulin Resistance / physiology*
  • Nuclear Receptor Subfamily 4, Group A, Member 1 / metabolism*


  • Blood Glucose
  • NR4A1 protein, human
  • Nuclear Receptor Subfamily 4, Group A, Member 1