Effect of parathyroid hormone on experimental tooth movement in rats

Am J Orthod Dentofacial Orthop. 2013 Oct;144(4):523-32. doi: 10.1016/j.ajodo.2013.05.010.


Introduction: The aim of this study was to investigate the effect of parathyroid hormone injection on experimental tooth movement in rats.

Methods: Sixty male Wistar rats were randomly divided into 2 groups. Their maxillary right first molars were moved mesially with nickel-titanium closed-coil springs. The experimental group received daily subcutaneous injections of parathyroid hormone at a dose of 4 μg per 100 g of body weight for 12 days, and the control group received vehicle injections. The results were evaluated by intraoral measurements and by hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemistry staining.

Results: The tooth movement and osteoclast numbers were significantly increased in the parathyroid hormone group compared with the control group. The expressions of receptor activator of nuclear factor kappa B ligand and insulin-like growth factor-I were significantly stimulated in the parathyroid hormone group.

Conclusions: The data suggest that short-term parathyroid hormone injection might be a potential method for accelerating orthodontic tooth movement by increasing the alveolar bone turnover rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Process / metabolism
  • Animals
  • Bone Remodeling / drug effects*
  • Insulin-Like Growth Factor I / biosynthesis
  • Male
  • Osteoclasts / drug effects*
  • Osteoclasts / metabolism
  • Osteoprotegerin / biosynthesis
  • Parathyroid Hormone / pharmacology*
  • RANK Ligand / biosynthesis
  • Rats
  • Rats, Wistar
  • Time Factors
  • Tooth Movement Techniques*


  • Osteoprotegerin
  • Parathyroid Hormone
  • RANK Ligand
  • Insulin-Like Growth Factor I