Hematopoietic defects and iPSC disease modeling: lessons learned

Immunol Lett. 2013 Sep-Oct;155(1-2):18-20. doi: 10.1016/j.imlet.2013.09.018. Epub 2013 Sep 25.

Abstract

Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis. Likewise, studying hematopoiesis and the defects that can arise offer clues to understanding general stem cell survival and differentiation.

Keywords: Bone marrow failure; Disease modeling; Induced pluripotent stem cells; Reprogramming.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cellular Reprogramming
  • Hematologic Diseases / genetics
  • Hematologic Diseases / pathology*
  • Hematologic Diseases / therapy
  • Hematopoiesis*
  • Hematopoietic Stem Cell Transplantation*
  • Hematopoietic Stem Cells / physiology*
  • Hemoglobins / genetics
  • Hemoglobins / metabolism
  • Humans
  • Induced Pluripotent Stem Cells / physiology*
  • Mutation / genetics

Substances

  • Hemoglobins