IFITMs restrict the replication of multiple pathogenic viruses

J Mol Biol. 2013 Dec 13;425(24):4937-55. doi: 10.1016/j.jmb.2013.09.024. Epub 2013 Sep 25.


The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.

Keywords: AS; CCHFV; CD225 family; CIL; CMEM; Crimean Congo hemorrhagic fever virus; DENV; EBOV; Ebola virus; GP; HCV; HIV-1; IAV; IFITM; IFN; JSRV; Jaagsiekte sheep retrovirus; MARV; MLV; MS; Marburg virus; Moloney leukemia virus; N-terminal domain; NTD; OSBP; RVFV; Rift Valley fever virus; SARS CoV; SeV; Sendai virus; VAPA; alanine scanning; clathrin-mediated endocytosis motif; conserved intracellular loop; dengue virus; glycoprotein; hepatitis C virus; host virus interactions; human immunodeficiency virus type 1; influenza A virus; interferon; interferon effector genes; interferon-inducible transmembrane protein; mass spectrometry; oxysterol binding protein; restriction factor; severe acute respiratory syndrome coronavirus; vesicle-associated membrane protein-A.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Differentiation / chemistry
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / metabolism
  • Dengue Virus / immunology*
  • Dengue Virus / physiology
  • Ebolavirus / immunology*
  • Ebolavirus / physiology
  • Hepacivirus / immunology*
  • Hepacivirus / physiology
  • Host-Pathogen Interactions
  • Humans
  • Influenza A virus / immunology*
  • Influenza A virus / physiology
  • Interferons / genetics
  • Interferons / metabolism
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Mice
  • Models, Immunological
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Sequence Alignment
  • Virus Internalization
  • Virus Replication / immunology*


  • Antigens, Differentiation
  • Membrane Proteins
  • leu-13 antigen
  • Interferons