Germinoma in two brothers: case report

Neurol Med Chir (Tokyo). 2013;53(10):703-6. doi: 10.2176/nmc.cr2012-0143. Epub 2013 Sep 27.

Abstract

We present a third reported case of intracranial germinomas occurring in two brothers. They underwent chemotherapy and radiotherapy after biopsy and are doing well for 10 years and 20 months, respectively. The pertinent literatures are reviewed, and the possible role of heredity in the pathogenesis of familial occurrence of germinomas is discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Child
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cranial Irradiation
  • Craniotomy
  • Dwarfism / etiology
  • Etoposide / administration & dosage
  • Family Health
  • Germinoma / complications
  • Germinoma / drug therapy
  • Germinoma / genetics*
  • Germinoma / pathology
  • Germinoma / radiotherapy
  • Germinoma / surgery
  • Humans
  • Hydrocephalus / etiology
  • Hydrocephalus / surgery
  • Hypothyroidism / etiology
  • Intellectual Disability / etiology
  • Male
  • Siblings
  • Supratentorial Neoplasms / complications
  • Supratentorial Neoplasms / drug therapy
  • Supratentorial Neoplasms / genetics*
  • Supratentorial Neoplasms / pathology
  • Supratentorial Neoplasms / radiotherapy
  • Supratentorial Neoplasms / surgery
  • Tectum Mesencephali / pathology*
  • Ventriculoperitoneal Shunt
  • Vision Disorders / etiology
  • Young Adult

Substances

  • Etoposide
  • Cisplatin