The relationship of plasma neuropeptide Y levels with coronary collateral development

Coron Artery Dis. 2014 Jan;25(1):73-8. doi: 10.1097/MCA.0000000000000039.

Abstract

Objective: Neuropeptide Y (NPY), a sympathetic cotransmitter, has been shown to promote angiogenesis in in-vitro models. The aim of this study was to evaluate the relationship of plasma NPY levels with coronary collateral vessel development in patients with coronary artery disease.

Methods: The study included 81 patients with at least one coronary stenosis with at least 80% narrowing in coronary angiography. Collateral vessels were graded according to the Rentrop classification. The study patients were divided into two groups, namely patients with well-developed collaterals and patients with poorly developed collaterals. Well-developed collaterals were defined as Rentrop collateral score of at least 2. Plasma levels of NPY, vascular endothelial growth factor, fibroblast growth factor, and noradrenaline were measured using an enzyme-linked immunosorbent assay.

Results: Plasma NPY was significantly higher in patients with well-developed collaterals as compared with patients with poorly developed collaterals (P=0.026). In contrast, plasma noradrenaline was significantly lower in patients with well-developed collaterals (P=0.022). There was no statistically significant difference in vascular endothelial growth factor and fibroblast growth factor levels between groups. The NPY level was positively correlated with the presence of diabetes (r=0.528, P<0.001). The extent of coronary artery disease (Gensini score) was significantly higher in patients with well-developed collaterals (P<0.001). After confounding variables were controlled for, the NPY level in patients with well-developed collaterals was significantly higher than those patients with poorly developed collaterals.

Conclusion: In this study, NPY levels were found to be significantly higher in patients with well-developed coronary collaterals compared with patients with poorly developed collaterals. New studies are needed to show whether this relationship is causal.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Collateral Circulation*
  • Coronary Angiography
  • Coronary Circulation*
  • Coronary Stenosis / blood*
  • Coronary Stenosis / diagnosis
  • Coronary Stenosis / physiopathology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fibroblast Growth Factors / blood
  • Humans
  • Male
  • Middle Aged
  • Neuropeptide Y / blood*
  • Norepinephrine / blood
  • Prospective Studies
  • Severity of Illness Index
  • Vascular Endothelial Growth Factor A / blood

Substances

  • Biomarkers
  • Neuropeptide Y
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factors
  • Norepinephrine