Double-blind placebo and active (caffeine) controlled study to examine the effects of the herbal nutritional supplement beverage "Wake up" on vigilance and function after lunch

Isr Med Assoc J. 2013 Aug;15(8):419-23.

Abstract

Background: Post-lunch dip is a well-known phenomenon that results in a substantial deterioration in function and productivity after lunch.

Objectives: To assess whether a new herbal-based potentially wake-promoting beverage is effective in counteracting somnolence and reduced post-lunch performance.

Methods: Thirty healthy volunteers were studied on three different days at the sleep clinic. On each visit they ate a standard lunch at noontime, followed by a drink of "Wake up," 50 mg caffeine, or a placebo in a cross-over double-blind regimen. At 30 and 120 minutes post-drinking, they underwent a battery of tests to determine the effects of the beverage. These included: a) a subjective assessment of alertness and performance based on a visual analog scale, and b) objective function tests: the immediate word recall test, the digit symbol substitution test (DSST), and hemodynamic measurements. The results of the three visits were compared using one-way analysis of variance, with P < 0.05 considered statistically significant.

Results: In all performance tests, subjective vigilance and effectiveness assessment, both Wake up and caffeine were significantly superior to placebo 30 minutes after lunch. However, at 2 hours after lunch, performance had deteriorated in those who drank the caffeine-containing drink, while Wake up was superior to both caffeine and placebo. Blood pressure and pulse were higher 2 hours after caffeine ingestion, compared to both Wake up and placebo.

Conclusions: These results suggest that a single dose of Wake up is effective in counteracting the somnolence and reduced performance during the post-lunch hours. In the current study it had no adverse hemodynamic consequences.

Publication types

  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Beverages
  • Blood Pressure / drug effects
  • Caffeine / pharmacology
  • Cognition / drug effects
  • Cross-Over Studies
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Heart Rate / drug effects
  • Humans
  • Lunch
  • Male
  • Middle Aged
  • Plant Extracts / pharmacology*
  • Postprandial Period
  • Psychomotor Performance / drug effects*
  • Sleep Stages / drug effects
  • Time Factors
  • Treatment Outcome
  • Wakefulness / drug effects*
  • Young Adult

Substances

  • Plant Extracts
  • Caffeine