Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013;35(9):915-25.
doi: 10.1080/13803395.2013.838939. Epub 2013 Oct 1.

An Investigation of the Effects of Antiretroviral Central Nervous System Penetration Effectiveness on Procedural Learning in HIV+ Drug Users

Affiliations
Free PMC article

An Investigation of the Effects of Antiretroviral Central Nervous System Penetration Effectiveness on Procedural Learning in HIV+ Drug Users

Michael J Wilson et al. J Clin Exp Neuropsychol. .
Free PMC article

Abstract

Treatment with combination antiretroviral therapy (cART) regimens with a high capacity to penetrate the blood-brain barrier has been associated with lower levels of human immunodeficiency virus (HIV) in the central nervous system (CNS). This study examined neurocognitive performance among a sample of 118 HIV+ substance-dependent individuals (SDIs) and 310 HIV- SDIs. HIV+ participants were prescribed cART regimens with varying capacity to penetrate the CNS as indexed by the revised CNS Penetration Effectiveness (CPE) scale. Participants completed the Rotary Pursuit Task (RPT) and the Weather Prediction Task (WPT)-two measures of procedural learning (PL) with known sensitivity to HIV infection-and a control task of sustained attention. HIV+ SDIs prescribed cART with relatively high CNS penetrance performed significantly more poorly on both tasks than HIV- controls. Task performance of HIV+ SDIs prescribed cART with relatively low CNS penetrance did not differ significantly from either HIV- controls or the HIV+/high CPE group, although a trend toward lower RPT performance than that of HIV- participants was observed. Between-group differences were not seen on a control task of motor impulsivity (Immediate Memory Task), indicating that the observed deficits among HIV+/high CPE SDIs may have some specificity.

Figures

Figure 1
Figure 1
Distribution of total cART regimen CPE scores for HIV+ participants.
Figure 2
Figure 2
Mean time on target during the Rotary Pursuit Task (RPT) by HIV-seronegative, HIV+ Low CPE and HIV+ High CPE participants. Note. Error bars represent SEM.
Figure 3
Figure 3
Mean percentage of correct responses on the Weather Prediction Task (WPT) by HIV-seronegative, HIV+ Low CPE and HIV+ High CPE participants. Note. Error bars represent SEM.

Similar articles

See all similar articles

Cited by 3 articles

Publication types

Substances

Feedback