[Acute hepatitis E infection associated with Guillain-Barré syndrome in an immunocompetent patient]

Rev Med Interne. 2014 May;35(5):333-6. doi: 10.1016/j.revmed.2013.05.005. Epub 2013 Sep 27.
[Article in French]


Introduction: Hepatitis E virus (HEV) infection is now recognized to be an emerging autochthonous disease in several countries. There have been several reports of neurological manifestations associated with HEV infections. Immunocompromised patients seem to be particularly vulnerable.

Case report: We report a 73-year-old man who presented with an acute polyradiculopathy and an acute hepatitis. HEV RNA was positive in serum and cerebrospinal fluid. Serum antiganglioside antibodies were also detected. Liver function tests returned to normal rapidly and HEV RNA was undetectable 4 weeks after initial testing. The neurological features improved gradually with the use of intravenous immunoglobulins.

Conclusion: We report a case of Guillain-Barré syndrome related to acute hepatitis E in an immunocompetent patient. The outcome was favorable after intravenous immunoglobulins administration. HEV screening should be systematic in patients who present with an acute polyradiculopathy and abnormal liver function tests.

Keywords: Anticorps antigangliosides; Antiganglioside antibodies; Guillain-Barré syndrome; Hepatitis; Hepatitis E virus; Hépatite; Immunoglobulines intraveineuses; Intravenous immunoglobulin; Polyradiculonévrite; Polyradiculopathy; Syndrome de Guillain-Barré; Virus de l’hépatite E.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Disease
  • Aged
  • Guillain-Barre Syndrome / complications*
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / immunology
  • Hepatitis E / complications*
  • Hepatitis E / diagnosis
  • Hepatitis E / immunology
  • Humans
  • Immunocompetence*
  • Male