Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: single-point and longitudinal assessments

J Neuroimmunol. 2013 Nov 15;264(1-2):106-13. doi: 10.1016/j.jneuroim.2013.09.010. Epub 2013 Sep 18.

Abstract

Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n=44) or Tourette syndrome (n=40) as compared to controls (n=24). Anti-tubulin and D2 receptor antibodies assessed in serial samples from 12 PANDAS subjects obtained prior to a documented exacerbation, during the exacerbation (with or without a temporally associated streptococcal infection), and following the exacerbation, showed no evidence of antibody levels correlating with a clinical exacerbation. These data do not support hypotheses suggesting an autoimmune hypothesis in either TS or PANDAS.

Keywords: Anti-neuronal antibodies; D2 receptor; PANDAS; Single-point and longitudinal; Tourette syndrome; Tubulin.

MeSH terms

  • Adolescent
  • Antibodies / blood*
  • Bacterial Proteins / immunology
  • Child
  • Deoxyribonucleases / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Polyendocrinopathies, Autoimmune / blood*
  • Polyendocrinopathies, Autoimmune / complications
  • Polyendocrinopathies, Autoimmune / immunology
  • Receptors, Dopamine D2 / immunology*
  • Streptolysins / immunology*
  • Tourette Syndrome / blood*
  • Tourette Syndrome / complications
  • Tubulin / immunology*

Substances

  • Antibodies
  • Bacterial Proteins
  • Receptors, Dopamine D2
  • Streptolysins
  • Tubulin
  • streptolysin O
  • Deoxyribonucleases