Biomarkers and creatinine in AKI: the trough of disillusionment or the slope of enlightenment?

Kidney Int. 2013 Oct;84(4):644-7. doi: 10.1038/ki.2013.168.


Assessment of acute kidney biomarkers against changes in plasma creatinine is beset by issues of heterogeneity of study cohorts and timing of sampling. Siew and colleagues attempt to minimize these issues in a case-control study of three biomarkers in the intensive care unit. The results highlight the inherent methodological difficulties and the need to reference structural injury biomarkers against more meaningful outcomes.

Publication types

  • Comment

MeSH terms

  • Acute Kidney Injury / diagnosis*
  • Acute Kidney Injury / urine*
  • Acute-Phase Proteins / urine*
  • Critical Illness*
  • Cystatin C / urine*
  • Fatty Acid-Binding Proteins / urine*
  • Female
  • Humans
  • Kidney / physiology*
  • Lipocalin-2
  • Lipocalins / urine*
  • Male
  • Proto-Oncogene Proteins / urine*


  • Acute-Phase Proteins
  • Cystatin C
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Proto-Oncogene Proteins