Clinical and serological follow-up of patients with polyarthritis, Raynaud's phenomenon, and circulating RNP antibodies

Scand J Rheumatol. 1990;19(1):51-6. doi: 10.3109/03009749009092621.


Fourteen patients with polyarthritis, Raynaud's phenomenon/sclerodactyly, and circulating (U1)RNP antibodies were followed up for 10 years. All patients could be classified as having the mixed connective tissue disease at the end of the follow-up. The immunoblotting analysis revealed marked heterogeneity in the ribonucleoprotein antibody profiles. The antibodies were mainly of the IgG isotype but in four sera only IgA and/or IgM type antibodies were demonstrated. Three patients who were found to have anti-RNP by the immunodiffusion assay proved negative for anti-U-RNP antibodies by immunoblotting. Patients with antibodies against the BB' polypeptides of U-RNP particles had a disease characterized by non-erosive arthritis, sclerodactyly and cutaneous manifestations. Patients who had antibodies against the 70 kD polypeptide of U1-RNP particles only had an erosive polyarthritis. However, these patients did not tolerate treatment with either gold salts or with D-penicillamine. Thus, the classification of the RNP antibodies by immunoblotting technique seemed to define patient groups whose disease took differing courses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Inflammatory Agents / therapeutic use
  • Antibodies, Antinuclear / analysis
  • Antigen-Antibody Reactions*
  • Arthritis / complications
  • Arthritis / drug therapy
  • Arthritis / immunology*
  • Autoantibodies / analysis*
  • Autoantibodies / immunology
  • Autoantigens / immunology*
  • Female
  • Fluorescent Antibody Technique
  • Follow-Up Studies
  • Humans
  • Immunoblotting
  • Immunoglobulins / analysis
  • Male
  • Middle Aged
  • Raynaud Disease / immunology
  • Raynaud Disease / physiopathology*
  • snRNP Core Proteins


  • Anti-Inflammatory Agents
  • Antibodies, Antinuclear
  • Autoantibodies
  • Autoantigens
  • Immunoglobulins
  • snRNP Core Proteins