Clinical implication of crescentic lesions in immunoglobulin A nephropathy

Nephrol Dial Transplant. 2014 Feb;29(2):356-64. doi: 10.1093/ndt/gft398. Epub 2013 Sep 29.


Background: To date, there has been much controversy about the role of crescentic lesion as a significant prognostic factor in immunoglobulin A nephropathy (IgAN). This study evaluated whether crescentic lesions predict adverse renal outcomes in IgAN patients.

Methods: A total of 430 patients with biopsy-proven IgAN between January 2000 and December 2009 were included. Histological variables of the Oxford classification (Oxford-MEST) and the presence of crescents were assessed. The primary endpoint was a 50% decline in estimated glomerular filtration rate.

Results: Of the 430 patients, 81 (18.8%) had a crescentic lesion. During a mean follow-up of 61 months, the primary outcome occurred in 19 (23.5%) patients with crescents compared with 40 (11.5%) patients without crescents (P=0.01). A Kaplan-Meier plot showed that the 10-year renal survival rate was significantly lower in patients with crescents than patients without crescents (P=0.01). However, in a multivariable Cox analysis which included clinical factors and the Oxford-MEST, crescents were not significantly associated with an increased risk of developing the primary outcome [hazard ratio: 0.71, 95% confidence interval (CI) 0.36-1.41, P=0.33]. Furthermore, adding crescents to the Oxford-MEST did not improve the discriminative ability for the prediction of renal outcomes [c-statistic: 0.86 (0.81-0.91) vs. 0.86 (0.80-0.91), P=0.21].

Conclusion: Crescentic lesion was not an independent prognostic factor, suggesting that crescents have limited value in predicting renal outcomes of IgAN.

Keywords: Oxford classification; crescents; immunoglobulin a nephropathy; outcome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate*
  • Glomerulonephritis, IGA / complications
  • Glomerulonephritis, IGA / pathology*
  • Glomerulonephritis, IGA / physiopathology
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Kidney / pathology*
  • Kidney / physiopathology
  • Kidney Failure, Chronic / epidemiology
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / pathology
  • Male
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • Republic of Korea / epidemiology
  • Retrospective Studies
  • Survival Rate / trends
  • Time Factors
  • Young Adult