Copper-mediated amidation of alkenylzirconocenes with acyl azides: formation of enamides

Hailan Liu; Yiqing Zhou; Xiaoyu Yan; Chao Chen; Qingbin Liu; Chanjuan Xi

doi:10.1021/ol402212g

Copper-mediated amidation of alkenylzirconocenes with acyl azides: formation of enamides

Org Lett. 2013 Oct 18;15(20):5174-7. doi: 10.1021/ol402212g. Epub 2013 Oct 1.

Authors

Hailan Liu¹, Yiqing Zhou, Xiaoyu Yan, Chao Chen, Qingbin Liu, Chanjuan Xi

Affiliation

¹ Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China , and Institute of Chemistry and Chemical Engineering, Hebei Normal University , Shijiazhuang 050091, China.

PMID: 24083640
DOI: 10.1021/ol402212g

Abstract

Copper-mediated amidation of alkenylzirconocenes generated in situ from alkynes and zirconocenes with acyl azides is accomplished under mild conditions. The reaction can be used to prepare various enamides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry*
Amides / chemical synthesis*
Amides / chemistry
Azides / chemistry*
Catalysis
Copper / chemistry*
Molecular Structure
Organometallic Compounds / chemistry*
Zirconium / chemistry*

Substances

Alkynes
Amides
Azides
Organometallic Compounds
Copper
Zirconium
cupric chloride