Abstract
During the search for new antitrypanosomal drug leads, three new antitrypanosomal compounds, cardinalisamides A-C (1-3), were isolated from cultures of the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. Their structures were elucidated using MS analyses and extensive 2D-heteronuclear NMR. The absolute configurations of 1-3 were addressed by chemical degradation and Marfey's analysis. 1-3 showed in vitro antitrypanosomal activity against Trypanosoma brucei brucei with IC50 values of 8.56, 8.65 and 8.63 μg ml(-1), respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cordyceps / chemistry*
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification
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Depsipeptides / pharmacology*
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Drug Discovery
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Humans
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Lepidoptera / microbiology*
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology*
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Trypanosoma brucei brucei / drug effects
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Trypanosomiasis, African / drug therapy
Substances
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Depsipeptides
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Trypanocidal Agents
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cardinalisamide A
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cardinalisamide B
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cardinalisamide C