The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1

Cell. 1985 Jul;41(3):665-76. doi: 10.1016/s0092-8674(85)80047-7.


The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen. Similarly, the receptor for the murine colony-stimulating factor, CSF-1, is restricted to cells of the mononuclear phagocytic lineage and is a 165 kd glycoprotein with an associated tyrosine kinase. Rabbit antisera to a recombinant v-fms-coded polypeptide precipitated the feline c-fms product and specifically cross-reacted with a 165 kd glycoprotein from mouse macrophages. This putative product of the murine c-fms gene exhibited an associated tyrosine kinase activity in immune complexes, specifically bound murine CSF-1, and, in the presence of the growth factor, was phosphorylated on tyrosine in membrane preparations. The murine c-fms proto-oncogene product and the CSF-1 receptor are therefore related, and possibly identical, molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Cats
  • Cell Line
  • Cross Reactions
  • DNA, Recombinant
  • Epitopes
  • Glycoproteins / genetics
  • Glycoproteins / immunology
  • Immune Sera / immunology
  • Macrophages / metabolism*
  • Mice
  • Oncogenes*
  • Phosphorylation
  • Protein Kinases / metabolism
  • Protein-Tyrosine Kinases
  • Receptors, Cell Surface / biosynthesis
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / immunology
  • Receptors, Cell Surface / metabolism
  • Receptors, Colony-Stimulating Factor
  • Viral Proteins / genetics
  • Viral Proteins / immunology


  • Antibodies, Monoclonal
  • DNA, Recombinant
  • Epitopes
  • Glycoproteins
  • Immune Sera
  • Receptors, Cell Surface
  • Receptors, Colony-Stimulating Factor
  • Viral Proteins
  • Protein Kinases
  • Protein-Tyrosine Kinases