Factors predicting early deterioration in mild brain trauma: a prospective study

Brain Inj. 2013;27(13-14):1666-70. doi: 10.3109/02699052.2013.830333. Epub 2013 Oct 2.

Abstract

Primary objective: To evaluate risk factors for clinical deterioration in mild traumatic brain injury.

Research design: Prospective cross-sectional.

Methods and procedures: This study evaluated 203 patients with mild traumatic brain injury. A brain computed tomography scan was performed in all patients and they were observed for 6-48 hours.

Main outcomes and results: Among these patients, 2.5% had cerebral contusions and the most common sites for contusions were frontal lobes; 94% of patients had no hematoma in the initial scan, while 3% had subgaleal haematoma, 1.5% had subdural haematoma, 1% showed subarachnoid haemorrhage, 0.5% intracerebral haemorrhage and 0.5% epidural haemorrhage. GCS was 15 in 96.6% and 13-14 in 3.4%. GCS deteriorated in three (1.5%). Presence of coagulopathy, anticoagulant drug use, GCS of 13-14 and increased age predicted further deterioration. Among CT findings, those with midline shift, cerebral contusion and diffuse cerebral oedema deteriorated more. Among different haematoma types, only SDH predicted a worse outcome.

Conclusions: Although deterioration rarely occurs in patients with mild brain injury, those with coagulopathy, anticoagulant drug use, GCS of 13-14, increased age, midline shift, cerebral contusions, diffuse cerebral oedema and SDH were more prone to deterioration.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Anticoagulants / adverse effects*
  • Brain Edema / diagnostic imaging
  • Brain Edema / etiology
  • Brain Edema / physiopathology*
  • Brain Injuries / complications
  • Brain Injuries / diagnostic imaging
  • Brain Injuries / physiopathology*
  • Cross-Sectional Studies
  • Female
  • Glasgow Coma Scale
  • Humans
  • Intracranial Hemorrhage, Traumatic / diagnostic imaging
  • Intracranial Hemorrhage, Traumatic / etiology
  • Intracranial Hemorrhage, Traumatic / physiopathology*
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Risk Factors
  • Tomography, X-Ray Computed*

Substances

  • Anticoagulants