Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats

BMC Complement Altern Med. 2013 Oct 3;13:253. doi: 10.1186/1472-6882-13-253.


Background: Hericium erinaceus, as a commonly used medicine or food, has attracted much attention due to its health effects when used as a home remedy for some diseases. The aim of this work was to investigate the hypoglycemic and hypolipidemic effects of aqueous extract of Hericium erinaceus (AEHE) in streptozotocin (STZ)-induced diabetic rats.

Methods: Diabetes was induced in Wistar rats by the administration of STZ (55 mg/kg BW.) intraperitoneally. AEHE (100 and 200 mg/kg BW.) was administered for a period of 28 days. The effects of AEHE on glucose, insulin, and lipid files in blood, and oxidative stress parameters in the liver were evaluated. The body weights of rats were recorded at day 0, 14 and 28th days.

Results: The administration of AEHE for 28 days in STZ diabetic rats resulted in a significant decrease in serum glucose level and a significant rise in serum insulin level. AEHE treatment attenuated lipid disorders. In addition, AEHE administration increased the activities of CAT, SOD, and GSH-Px, and GSH level, and reduced MDA level in the liver tissue significantly.

Conclusion: Our results suggest that AEHE possesses hypoglycemic, hypolipidemic, and antioxidant properties in STZ-induced diabetes rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basidiomycota / chemistry*
  • Biomarkers / analysis
  • Blood Glucose / drug effects*
  • Body Weight
  • Cholesterol / blood*
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology
  • Insulin / blood
  • Liver / chemistry
  • Liver / drug effects
  • Male
  • Oxidative Stress / drug effects
  • Rats
  • Rats, Wistar
  • Triglycerides / blood


  • Biomarkers
  • Blood Glucose
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Insulin
  • Triglycerides
  • Cholesterol