How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

doi:10.1007/s00204-013-1127-0

Editorial

. 2014 Jan;88(1):5-7.

doi: 10.1007/s00204-013-1127-0. Epub 2013 Oct 4.

How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

Bernd Mayer¹

Affiliations

PMID: 24091634
PMCID: PMC3880486
DOI: 10.1007/s00204-013-1127-0

Editorial

How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

Bernd Mayer. Arch Toxicol. 2014 Jan.

. 2014 Jan;88(1):5-7.

doi: 10.1007/s00204-013-1127-0. Epub 2013 Oct 4.

Author

Bernd Mayer¹

Affiliation

¹ Department of Pharmacology and Toxicology, Karl-Franzens University Graz, Univ.-Platz 2, 8010, Graz, Austria, mayer@uni-graz.at.

PMID: 24091634
PMCID: PMC3880486
DOI: 10.1007/s00204-013-1127-0

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References

1. Corkery JM, Button J, Vento AE, Schifano F. Two UK suicides using nicotine extracted from tobacco employing instructions available on the Internet. Forensic Sci Int. 2010;199:e9–e13. doi: 10.1016/j.forsciint.2010.02.004. - DOI - PubMed
1. Esser A, Kühn A. Nikotin-vergiftungen, akute. Arch Toxicol. 1933;4:C29–C36. doi: 10.1007/BF02462731. - DOI
1. Gourlay SG, Benowitz NL. Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine. Clin Pharmacol Ther. 1997;62:453–463. doi: 10.1016/S0009-9236(97)90124-7. - DOI - PubMed
1. Hayes WJ (1982) Pesticides studied in man. Lippincott Williams & Wilkins, Baltimore, pp 86–91
1. Henningfield JE, Miyasato K, Jasinski DR. Cigarette smokers self-administer intravenous nicotine. Pharmacol Biochem Behav. 1983;19:887–890. doi: 10.1016/0091-3057(83)90099-0. - DOI - PubMed

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[1] Corkery JM, Button J, Vento AE, Schifano F. Two UK suicides using nicotine extracted from tobacco employing instructions available on the Internet. Forensic Sci Int. 2010;199:e9–e13. doi: 10.1016/j.forsciint.2010.02.004. - DOI - PubMed

[2] Corkery JM, Button J, Vento AE, Schifano F. Two UK suicides using nicotine extracted from tobacco employing instructions available on the Internet. Forensic Sci Int. 2010;199:e9–e13. doi: 10.1016/j.forsciint.2010.02.004. - DOI - PubMed

[3] Esser A, Kühn A. Nikotin-vergiftungen, akute. Arch Toxicol. 1933;4:C29–C36. doi: 10.1007/BF02462731. - DOI

[4] Esser A, Kühn A. Nikotin-vergiftungen, akute. Arch Toxicol. 1933;4:C29–C36. doi: 10.1007/BF02462731. - DOI

[5] Gourlay SG, Benowitz NL. Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine. Clin Pharmacol Ther. 1997;62:453–463. doi: 10.1016/S0009-9236(97)90124-7. - DOI - PubMed

[6] Gourlay SG, Benowitz NL. Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine. Clin Pharmacol Ther. 1997;62:453–463. doi: 10.1016/S0009-9236(97)90124-7. - DOI - PubMed

[7] Hayes WJ (1982) Pesticides studied in man. Lippincott Williams & Wilkins, Baltimore, pp 86–91

[8] Hayes WJ (1982) Pesticides studied in man. Lippincott Williams & Wilkins, Baltimore, pp 86–91

[9] Henningfield JE, Miyasato K, Jasinski DR. Cigarette smokers self-administer intravenous nicotine. Pharmacol Biochem Behav. 1983;19:887–890. doi: 10.1016/0091-3057(83)90099-0. - DOI - PubMed

[10] Henningfield JE, Miyasato K, Jasinski DR. Cigarette smokers self-administer intravenous nicotine. Pharmacol Biochem Behav. 1983;19:887–890. doi: 10.1016/0091-3057(83)90099-0. - DOI - PubMed

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How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

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How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century

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