Antigenic cross-reactivity between caprine arthritis-encephalitis, visna and progressive pneumonia viruses involves all virion-associated proteins and glycoproteins

J Gen Virol. 1985 Jun;66 ( Pt 6):1233-40. doi: 10.1099/0022-1317-66-6-1233.

Abstract

Antigenic relatedness between the virion-associated proteins of caprine arthritis-encephalitis, visna and progressive pneumonia viruses was examined. Antigenic cross-reactivity was assessed by immunoprecipitation of disrupted, radiolabelled virus with goat, sheep and rabbit antisera, followed by resolution of the immunoprecipitation products by SDS-polyacrylamide gel electrophoresis. The results indicate that antigenic cross-reactivity between the caprine and ovine virus isolates involves all of the major virion-associated proteins and glycoproteins. The common antigenic determinants exhibited by virion structural proteins are immunogenic in goats, sheep and rabbits.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Viral / immunology*
  • Arthritis, Infectious / microbiology
  • Arthritis, Infectious / veterinary
  • Chemical Precipitation
  • Cross Reactions
  • Electrophoresis, Polyacrylamide Gel
  • Encephalitis / microbiology
  • Encephalitis / veterinary
  • Epitopes / immunology
  • Female
  • Glycoproteins / immunology*
  • Goats / immunology
  • Goats / microbiology*
  • Immunochemistry
  • Rabbits / immunology
  • Sheep / immunology
  • Viral Core Proteins
  • Viral Envelope Proteins / immunology
  • Viral Proteins / immunology*
  • Virion / immunology
  • Visna-maedi virus / immunology*

Substances

  • Antigens, Viral
  • Epitopes
  • Glycoproteins
  • Viral Core Proteins
  • Viral Envelope Proteins
  • Viral Proteins