Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma

Jolieke G van Oosterwijk; Jakob K Anninga; Hans Gelderblom; Anne-Marie Cleton-Jansen; Judith V M G Bovée

doi:10.1016/j.hoc.2013.07.012

Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma

Hematol Oncol Clin North Am. 2013 Oct;27(5):1021-48. doi: 10.1016/j.hoc.2013.07.012. Epub 2013 Aug 26.

Authors

Jolieke G van Oosterwijk¹, Jakob K Anninga, Hans Gelderblom, Anne-Marie Cleton-Jansen, Judith V M G Bovée

Affiliation

¹ Department of Pathology, Leiden University Medical Center, PO Box 9600, L1-Q, Leiden RC 2300, The Netherlands.

PMID: 24093174
DOI: 10.1016/j.hoc.2013.07.012

Abstract

Osteosarcoma and chondrosarcoma are the 2 most common malignant bone tumors. This review discusses the clinicopathologic features, recent preclinical developments, and targets currently being or to be validated in the clinic.

Keywords: Bone tumor; Chemotherapy; Chondrosarcoma; Hypoxia; Osteosarcoma; Sarcoma; Targeted therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Neoplasms / pathology*
Bone Neoplasms / therapy*
Chondrosarcoma / pathology*
Chondrosarcoma / therapy*
Humans
Neoplasm Grading
Osteosarcoma / pathology*
Osteosarcoma / therapy*