Influenza and endemic viral pneumonia

Crit Care Clin. 2013 Oct;29(4):1069-86. doi: 10.1016/j.ccc.2013.06.003.


Viruses are a common and important cause of severe community-acquired pneumonia, and may lead to severe respiratory disease and admission to the intensive care unit. Influenza is the most common virus associated with severe viral pneumonia, although other important causes include respiratory syncytial virus, adenovirus, metapneumonia virus, and coronaviruses. Viral pneumonias tend to have a seasonal predilection and are often preceded by a typical viral prodrome. This article focuses on severe influenza pneumonia, including the 2009 H1N1 pandemic, and briefly discusses other causes of severe respiratory disease of viral etiology.

Keywords: 2009 H1N1; Acute lung injury; Acute respiratory distress syndrome; Influenza; Viral pneumonia; Viral pneumonitis.

Publication types

  • Review

MeSH terms

  • Acute Lung Injury / epidemiology
  • Acute Lung Injury / virology*
  • Antiviral Agents / therapeutic use*
  • Endemic Diseases
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / complications*
  • Influenza, Human / epidemiology
  • Influenza, Human / transmission
  • Pandemics
  • Pneumonia, Viral* / epidemiology
  • Pneumonia, Viral* / virology
  • Respiratory Distress Syndrome, Adult / drug therapy
  • Respiratory Distress Syndrome, Adult / epidemiology
  • Respiratory Distress Syndrome, Adult / virology*


  • Antiviral Agents