Expression of the c-fms proto-oncogene during human monocytic differentiation

Nature. 1985 Jul 4-10;316(6023):64-6. doi: 10.1038/316064a0.

Abstract

The McDonough strain of the feline sarcoma virus contains a transforming gene (v-fms) which contains partial nucleotide homology with proto-oncogenes encoding tyrosine kinases. One of the v-fms-encoded products, gp140fms, is a cell surface transmembrane glycoprotein that may function as a growth factor receptor. Although c-fms transcripts have been detected in placental trophoblasts and normal human bone marrow, the role of the c-fms gene product is unknown. We now report that induction of monocytic, but not granulocytic, differentiation of human HL-60 leukaemic cells is associated with expression of c-fms, preceded by that of c-myc and c-fos. Because c-fms transcripts are also detectable in peripheral blood monocytes and in blasts from certain patients with myelomonocytic leukaemia, the c-fms gene product may play a role in monocytic differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetamides / pharmacology
  • Cell Differentiation*
  • Cell Line
  • Cycloheximide / pharmacology
  • Dimethyl Sulfoxide / pharmacology
  • Hematopoiesis
  • Humans
  • Leukemia, Myeloid
  • Monocytes / cytology*
  • Oncogenes*
  • RNA / analysis
  • Tetradecanoylphorbol Acetate / pharmacology
  • Transcription, Genetic / drug effects

Substances

  • Acetamides
  • RNA
  • Cycloheximide
  • hexamethylene bisacetamide
  • Tetradecanoylphorbol Acetate
  • Dimethyl Sulfoxide