Repair of strand breaks by homologous recombination

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012740. doi: 10.1101/cshperspect.a012740.


In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., homologous recombination [HR]), focusing mainly on yeast and mammals. We provide a historical context for the current view of HR and describe how DSBs are processed during HR as well as interactions with other DSB repair pathways. We discuss the enzymology of the process, followed by studies on DSB repair in living cells. Whenever possible, we cite both original articles and reviews to aid the reader for further studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • DNA Breaks, Double-Stranded*
  • DNA Repair*
  • DNA-Binding Proteins / metabolism
  • Genetic Engineering / methods
  • Homologous Recombination*
  • Humans
  • Meiosis
  • Plasmids / genetics
  • Rad51 Recombinase / metabolism
  • Recombination, Genetic
  • Saccharomyces cerevisiae / genetics


  • DNA-Binding Proteins
  • Rad51 Recombinase