Drug-induced acute liver failure

Clin Liver Dis. 2013 Nov;17(4):575-86, viii. doi: 10.1016/j.cld.2013.07.001. Epub 2013 Sep 4.


Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.

Keywords: Coagulopathy; Encephalopathy; Hepatocyte injury; Liver transplantation.

Publication types

  • Review

MeSH terms

  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / metabolism
  • Chemical and Drug Induced Liver Injury / therapy
  • Humans
  • Liver Failure, Acute / chemically induced*
  • Liver Failure, Acute / therapy