Nonsteroidal anti-inflammatory drug-induced hepatoxicity

Clin Liver Dis. 2013 Nov;17(4):643-56, ix. doi: 10.1016/j.cld.2013.07.009. Epub 2013 Sep 4.


Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.

Keywords: Acute liver injury; Drug safety; Drug surveillance; Drug-induced liver injury; Hy’s law; Idiosyncratic hepatotoxicity; Liver transplantation; Nonsteroidal anti-inflammatory drugs.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Humans
  • Product Surveillance, Postmarketing


  • Anti-Inflammatory Agents, Non-Steroidal