Isolated corymbose collagenoma responding to intralesional triamcinolone acetonide and hyaluronidase injections

Dermatol Ther. 2013 Sep-Oct;26(5):419-23. doi: 10.1111/dth.12016. Epub 2013 Mar 28.


Collagenomas are connective tissue nevi with circumscribed hamartomatous proliferation of collagen. Due to their benign nature and lack of any simple medical treatment, they are most often left untreated. We present a case of isolated corymbose collagenoma, a distinct morphological variant not described hitherto that was successfully treated with intralesional injections of combination of triamcinolone acetonide and hyaluronidase.

Keywords: intralesional injection; isolated collagenoma.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Collagen / metabolism
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hyaluronoglucosaminidase / administration & dosage
  • Hyaluronoglucosaminidase / therapeutic use*
  • Injections, Intralesional
  • Nevus / drug therapy*
  • Nevus / pathology
  • Treatment Outcome
  • Triamcinolone Acetonide / administration & dosage
  • Triamcinolone Acetonide / therapeutic use*


  • Collagen
  • Hyaluronoglucosaminidase
  • Triamcinolone Acetonide

Supplementary concepts

  • Connective Tissue Nevus