Transcriptional regulation by hypoxia inducible factors

Crit Rev Biochem Mol Biol. 2014 Jan-Feb;49(1):1-15. doi: 10.3109/10409238.2013.838205. Epub 2013 Oct 7.


The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Hypoxia / genetics
  • Hypoxia / metabolism*
  • Hypoxia-Inducible Factor 1 / chemistry
  • Hypoxia-Inducible Factor 1 / metabolism*
  • Protein Processing, Post-Translational
  • RNA Polymerase II / metabolism
  • Transcriptional Activation*


  • Hypoxia-Inducible Factor 1
  • RNA Polymerase II