Anticancer Activity of Liposomal Bergamot Essential Oil (BEO) on Human Neuroblastoma Cells

Colloids Surf B Biointerfaces. 2013 Dec 1;112:548-53. doi: 10.1016/j.colsurfb.2013.09.017. Epub 2013 Sep 17.

Abstract

Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications.

Keywords: Bergamot essential oil (BEO); Cancer; Citrus extracts; Liposomes; Natural products; SH-SY5Y human neuroblastoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Methoxypsoralen
  • Antineoplastic Agents, Phytogenic / administration & dosage*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Citrus / chemistry
  • Drug Delivery Systems
  • Humans
  • Liposomes / administration & dosage
  • Liposomes / chemistry
  • Methoxsalen / administration & dosage
  • Methoxsalen / analogs & derivatives
  • Neuroblastoma / drug therapy*
  • Neuroblastoma / pathology
  • Oils, Volatile / administration & dosage
  • Plant Oils / administration & dosage*
  • Solubility

Substances

  • Antineoplastic Agents, Phytogenic
  • Liposomes
  • Oils, Volatile
  • Plant Oils
  • bergamot oil
  • 5-Methoxypsoralen
  • Methoxsalen