No Evidence of Interaction Between Known Lipid-Associated Genetic Variants and Smoking in the Multi-Ethnic PAGE Population

Hum Genet. 2013 Dec;132(12):1427-31. doi: 10.1007/s00439-013-1375-3. Epub 2013 Oct 8.

Abstract

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cholesterol, HDL / metabolism
  • Cholesterol, LDL / metabolism
  • Cohort Studies
  • Ethnic Groups / genetics*
  • Female
  • Gene Frequency
  • Gene-Environment Interaction*
  • Genetics, Population
  • Genome-Wide Association Study / statistics & numerical data*
  • Humans
  • Lipid Metabolism / genetics*
  • Male
  • Polymorphism, Single Nucleotide*
  • Prevalence
  • Smoking / epidemiology
  • Smoking / ethnology
  • Smoking / genetics*
  • Smoking / metabolism
  • Triglycerides / metabolism
  • Young Adult

Substances

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides

Grant support