Akt2 relaxes podocytes in chronic kidney disease

Nat Med. 2013 Oct;19(10):1212-3. doi: 10.1038/nm.3357.


A signaling cascade is activated in podocytes to induce survival and cope with stress during advanced glomerular disease, a new study shows. The findings may also explain why the immunosuppressor sirolimus, an inhibitor of this pathway, can cause proteinuria in a subset of patients with chronic kidney disease (pages 1288–1296).

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Humans
  • Kidney Failure, Chronic / metabolism*
  • Podocytes / cytology*
  • Proto-Oncogene Proteins c-akt / physiology*


  • Akt2 protein, mouse
  • Proto-Oncogene Proteins c-akt