Genetic characterization of canine influenza A virus (H3N2) in Thailand

Virus Genes. 2014 Feb;48(1):56-63. doi: 10.1007/s11262-013-0978-z. Epub 2013 Oct 8.


In January 2012, several clinical cases of dogs with flu-like symptoms, including coughing, sneezing, nasal discharge, and fever, were reported in a small-animal hospital located in Bangkok, Thailand. One influenza A virus was identified and characterized as an avian-like influenza virus H3N2. The virus was named A/canine/Thailand/CU-DC5299/12. A phylogenetic analysis indicated that the canine virus belonged to an avian Eurasian lineage and was genetically related to the canine influenza viruses H3N2 from China and Korea. This canine virus displays a unique genetic signature with two amino acid insertions in the NA protein, which is similar to the canine influenza viruses from eastern China (Zhejiang and Jiangsu). This study constitutes the first report of H3N2 canine influenza virus infection in a small-animal hospital in Thailand.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cluster Analysis
  • Dog Diseases / virology*
  • Dogs
  • Female
  • Influenza A Virus, H3N2 Subtype / classification
  • Influenza A Virus, H3N2 Subtype / genetics*
  • Influenza A Virus, H3N2 Subtype / isolation & purification*
  • Male
  • Molecular Sequence Data
  • Mutagenesis, Insertional
  • Neuraminidase / genetics
  • Orthomyxoviridae Infections / veterinary*
  • Orthomyxoviridae Infections / virology
  • Phylogeny
  • Sequence Analysis, DNA
  • Sequence Homology
  • Thailand
  • Viral Proteins / genetics


  • Viral Proteins
  • NA protein, influenza A virus
  • Neuraminidase

Associated data

  • GENBANK/KC599545
  • GENBANK/KC599546
  • GENBANK/KC599547
  • GENBANK/KC599548
  • GENBANK/KC599549
  • GENBANK/KC599550
  • GENBANK/KC599551
  • GENBANK/KC599552