Protein kinase C isoforms at the neuromuscular junction: localization and specific roles in neurotransmission and development

J Anat. 2014 Jan;224(1):61-73. doi: 10.1111/joa.12106. Epub 2013 Sep 15.


The protein kinase C family (PKC) regulates a variety of neural functions including neurotransmitter release. The selective activation of a wide range of PKC isoforms in different cells and domains is likely to contribute to the functional diversity of PKC phosphorylating activity. In this review, we describe the isoform localization, phosphorylation function, regulation and signalling of the PKC family at the neuromuscular junction. Data show the involvement of the PKC family in several important functions at the neuromuscular junction and in particular in the maturation of the synapse and the modulation of neurotransmission in the adult.

Keywords: electrical stimulation; immunofluorescence; isoforms; neuromuscular junction; neurotransmission; protein kinase C; synapse elimination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Humans
  • Neuromuscular Junction / enzymology*
  • Neuromuscular Junction / physiology
  • Phosphorylation / physiology
  • Protein Isoforms / physiology
  • Protein Kinase C / physiology*
  • Synaptic Transmission / physiology*


  • Protein Isoforms
  • Protein Kinase C