Favorable outcome of an acute complex regional pain syndrome with immunoglobulin infusions

Clin J Pain. 2013 Nov;29(11):e33-4. doi: 10.1097/AJP.0b013e318292189e.


Objective: To emphasize that complex regional pain syndrome (CRPS), a disabling disorder with the implication of aberrant inflammation, vasomotor dysfunction, and maladaptive neuroplasticity, might be treated with a high dose of intravenous immunoglobulin infusions (IVIG).

Methods: We describe a patient who presented with CRPS in the acute phase of the disease.

Results: The CRPS developed secondary to sciatic compression in a young patient and was treated within 10 days by high-dose IVIG (2 g/kg). It resolved completely within days after infusions.

Discussion: This observational study emphasizes that high-dose IVIG may be a treatment option in the acute phase of CRPS.

Publication types

  • Case Reports

MeSH terms

  • Complex Regional Pain Syndromes / drug therapy*
  • Complex Regional Pain Syndromes / immunology
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Immunologic Factors / therapeutic use*
  • Male
  • Young Adult


  • Immunoglobulins, Intravenous
  • Immunologic Factors