Postsynaptic assembly: a role for Wnt signaling

Dev Neurobiol. 2014 Aug;74(8):818-27. doi: 10.1002/dneu.22138. Epub 2013 Nov 15.


Synapse formation requires the coordinated formation of the presynaptic terminal, containing the machinery for neurotransmitter release, and the postsynaptic side that possesses the machinery for neurotransmitter reception. For coordinated pre- and postsynaptic assembly signals across the synapse are required. Wnt secreted proteins are well-known synaptogenic factors that promote the recruitment of presynaptic components in diverse organisms. However, recent studies demonstrate that Wnts act directly onto the postsynaptic side at both central and peripheral synapses to promote postsynaptic development and synaptic strength. This review focuses on the role of Wnts in postsynaptic development at central synapses and the neuromuscular junction.

Keywords: dendritic spines; excitatory and inhibitory synapse; neuromuscular junction; synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Neuromuscular Junction / metabolism*
  • Neurotransmitter Agents / metabolism*
  • Synapses / metabolism*
  • Synaptic Potentials / physiology*
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway*


  • Neurotransmitter Agents
  • Wnt Proteins