Development of multiple stimuli responsive magnetic polymer nanocontainers as efficient drug delivery systems

Macromol Biosci. 2014 Jan;14(1):131-41. doi: 10.1002/mabi.201300212. Epub 2013 Sep 17.

Abstract

Magnetic nanodevices based on poly[(methacrylic acid)-co-(N-isopropylacrylamide)] [P(MAA-co-NIPAAm)] are prepared and used as drug delivery systems employing daunorubicin (DNR) as a model drug. The magnetic nanocontainers exploit the pH, temperature, and magnetic response of the polymeric shell constituents and magnetic nanoparticles, respectively, for controlled pH, temperature and alternating magnetic field triggered drug release. The in vitro cytotoxicity of both DNR-loaded and empty nanocontainers is examined on MCF-7 breast cancer cells along with the intracellular distribution of DNR. The results show that the DNR-loaded nanocontainers have an anti-tumor effect comparable to the free drug. The current observations provide important information for potent drug delivery and release systems.

Keywords: drug delivery systems; magnetic polymers; nanocontainers; pH response; temperature response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Daunorubicin / administration & dosage
  • Drug Delivery Systems / methods*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • MCF-7 Cells / drug effects
  • Magnetic Phenomena
  • Microscopy, Confocal
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry*
  • Polymethacrylic Acids / chemistry*
  • Temperature

Substances

  • Acrylamides
  • Polymethacrylic Acids
  • poly(N-isopropylacrylamide-co-methacrylic acid)
  • Daunorubicin