Acupuncture modulates the neuro-endocrine-immune network

QJM. 2014 May;107(5):341-5. doi: 10.1093/qjmed/hct196. Epub 2013 Oct 8.


As a nonspecific physical stimulation, the effect of acupuncture on diseases is produced by motivating the inherent regulatory system in the body, having the characteristics of whole regulation, dual directional regulation, etc. Modern scientific researches show that body's inherent regulatory system is neuro-endocrine-immune (NEI) network. Hence, we speculate that the regulatory effect of acupuncture may be produced through its regulation of NEI network. In this article, we reviewed the recent researches about acupuncture's effect on the NEI network, to find out the evidence of acupuncture adjusting NEI network and provide some evidences for revealing the mechanism of acupuncture.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acupuncture Therapy*
  • Humans
  • Immune System / physiology*
  • Immunity, Cellular / physiology
  • Immunity, Humoral / physiology
  • Neuroimmunomodulation / physiology
  • Neurosecretory Systems / immunology*
  • Physical Stimulation