Abstract
A novel route to synthesize the biologically active benzimidazolopyrazine core is outlined. The reaction proceeds via tandem benzimidazole formation/annulations of indole, pyrrole and aliphatic δ-alkynyl aldehydes in the presence of copper salts and green solvents with moderate to good yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Benzimidazoles / chemistry*
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Catalysis
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Copper / chemistry*
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Magnetic Resonance Spectroscopy
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Pyrazines / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
Substances
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Aldehydes
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Benzimidazoles
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Pyrazines
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Copper
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benzimidazole