A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by oncogene inactivation

Annu Int Conf IEEE Eng Med Biol Soc. 2013:2013:4529-32. doi: 10.1109/EMBC.2013.6610554.


Understanding the complex dynamics between the tumor cells and the host immune system will be key to improved therapeutic strategies against cancer. We propose an ODE-based mathematical model of both the tumor and immune system and how they respond to inactivation of the driving oncogene. Our model supports experimental results showing that cellular senescence of tumor cells is dependent on CD4+ T helper cells, leading to relapse of tumors in immunocompromised hosts.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Cellular Senescence / immunology
  • Humans
  • Immune System / immunology
  • Models, Theoretical*
  • Neoplasms / pathology*
  • Oncogenes
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / metabolism