Beat to beat variability of embryonic chick heart cells under septic conditions: application and evaluation of entropy as well as fractal measures

Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:5566-9. doi: 10.1109/EMBC.2013.6610811.


Extracardiac factors of heart rate variability have commonly been investigated using linear and nonlinear methods for a long time. Recently, intracardiac mechanisms on an electrophysiological basis have been found to be also important. This work is focused on the evaluation of complex measures of temporal signals gained with microelectrode measurements of embryonic chick heart aggregates. Septic conditions were mimicked in vitro by lipopolysaccharide (LPS) administration in order to investigate the influence on beat to beat variability. Surrogate data analysis revealed high statistical significances for normalized complexity measures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • Entropy*
  • Fractals*
  • Heart / embryology*
  • Heart / physiopathology*
  • Heart Rate / physiology*
  • Lipopolysaccharides / pharmacology
  • Myocytes, Cardiac / drug effects
  • Sepsis / embryology*
  • Sepsis / physiopathology*
  • Signal Processing, Computer-Assisted


  • Lipopolysaccharides