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Review
, 42 (1), 25-32

Chromosome 9p21 Primary Open-Angle Glaucoma Susceptibility Locus: A Review

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Review

Chromosome 9p21 Primary Open-Angle Glaucoma Susceptibility Locus: A Review

Soo Khai Ng et al. Clin Exp Ophthalmol.

Abstract

Primary open-angle glaucoma (POAG) is a genetically complex disease. Genome-wide association study (GWAS) is a particularly useful tool in the search for genetic contributions to glaucoma. Recently, chromosome 9p21 has become a major focus of research endeavour, with multiple genome-wide association studies suggesting associations to POAG. Herein, we provide a review of the chromosome 9p21 susceptibility locus as a risk factor for POAG.

Keywords: 9p21; CDKN2A; CDKN2B; CDKN2B-AS1..

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