Ibogaine related sudden death: a case report

J Forensic Leg Med. 2013 Oct;20(7):809-11. doi: 10.1016/j.jflm.2013.06.032. Epub 2013 Aug 5.

Abstract

Ibogaine is a naturally occurring alkaloid derived from the roots of the rain forest shrub Tabernanthe iboga. Deaths have occurred temporarily related to the use of ibogaine. However, although not licensed as therapeutic drug, and despite evidence that ibogaine may disturb the rhythm of the heart, this alkaloid is currently used as an anti-addiction drug in alternative medicine for detoxification purposes. We report the case of a man who died suddenly 12-24 h after ibogaine use for alcohol detoxification treatment. In the autopsy liver cirrhosis and heavy fatty infiltration was found. The concentration of ibogaine was 2 mg/l. The potential risks of ibogaine use, especially for persons with pathological medical background, are discussed.

Keywords: Autopsy; Cardiac death; Death; Fatty infiltration of the liver; Ibogaine.

Publication types

  • Case Reports

MeSH terms

  • Alcoholism / drug therapy*
  • Coronary Artery Disease / pathology
  • Death, Sudden, Cardiac / etiology*
  • Excitatory Amino Acid Antagonists / administration & dosage
  • Excitatory Amino Acid Antagonists / adverse effects*
  • Fatty Liver, Alcoholic / pathology
  • Humans
  • Ibogaine / administration & dosage
  • Ibogaine / adverse effects*
  • Liver Cirrhosis / pathology
  • Male
  • Middle Aged
  • Substance Withdrawal Syndrome / drug therapy

Substances

  • Excitatory Amino Acid Antagonists
  • Ibogaine