Long-term effects of repeated methylamphetamine administration on monoamine neurons in the rhesus monkey brain

Brain Res. 1985 Jul 15;338(2):243-8. doi: 10.1016/0006-8993(85)90153-2.


Previous studies indicate that the repeated administration of D-methylamphetamine (MA) produces a long-lasting depletion of dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) in various brain regions of a number of species. The objectives of the present study were: (1) to establish a short, subcutaneous injection regimen which would reliably produce the neuronal alterations; (2) to evaluate MA-induced NE depletions produced by this new regimen; and (3) to determine whether central MA-induced neuronal changes are reflected in changes in cerebrospinal fluid monoamine metabolite concentrations. It was observed that high doses of MA administered (s.c.) over a 2-week period to rhesus monkeys produced decreases in DA and 5-HT, but not NE levels, in various brain regions. The decrease in caudate DA levels was accompanied by a decrease in the number of DA uptake sites, a decrease in the level of homovanillic acid (HVA) and an increase in DA turnover. This decrease in brain DA was also accompanied by a decrease in the cerebrospinal fluid concentration of HVA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biogenic Amines / analysis*
  • Brain Chemistry*
  • Dihydroxyphenylalanine / analysis
  • Dopamine / analysis
  • Female
  • Homovanillic Acid / analysis
  • Hydroxyindoleacetic Acid / analysis
  • Macaca mulatta
  • Male
  • Methamphetamine / pharmacology*
  • Norepinephrine / analysis
  • Serotonin / analysis


  • Biogenic Amines
  • Serotonin
  • Methamphetamine
  • Hydroxyindoleacetic Acid
  • Dihydroxyphenylalanine
  • Dopamine
  • Norepinephrine
  • Homovanillic Acid