Fasting plasma adropin concentrations correlate with fat consumption in human females

Obesity (Silver Spring). 2014 Apr;22(4):1056-63. doi: 10.1002/oby.20631. Epub 2013 Oct 17.

Abstract

Objective: This study investigated whether plasma adropin concentrations are influenced by sleep restriction and correlate with dietary preferences.

Methods: Plasma adropin concentrations were measured by ELISA using samples from a study that investigated feeding behavior in sleep deprived lean (body mass index 22-26 kg/m(2) ) men and women aged 30-45 y. Sleep (habitual or restricted to 4h/night) and diet were controlled during a 4-day inpatient period. On day 5, food was self-selected (FS). Adropin was measured on day 4 in samples collected throughout the day, and then after an overnight fast at 0730 on days 5 (Pre-FS) and 6 (Post-FS).

Results: Plasma adropin concentrations were not affected by sleep restriction. However, circulating adropin concentrations correlated with food selection preferences in women, irrespective of sleep status. Pre-FS adropin correlated positively with fat intake (total fat, r = 0.867, P < 0.05; saturated fat, r = 0.959, P < 0.01) and negatively with carbohydrate intake (r = -0.894, P < 0.05) as a percent total energy. Post-FS adropin correlated with total (r = 0.797, P < 0.05) and saturated fat intake (r = 0.945, P < 0.01), and negative with total carbohydrate intake (r = -0.929, P < 0.01). Pre-FS adropin also correlated with fat intake in kcal adjusted for body size (total fat, r = 0.852, P < 0.05; saturated fat, r = 0.927, P < 0.01).

Conclusions: Plasma adropin concentrations correlate with fat consumption in women.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Blood Proteins
  • Cross-Over Studies
  • Dietary Carbohydrates
  • Dietary Fats*
  • Eating / physiology
  • Fasting / blood*
  • Feeding Behavior / physiology*
  • Female
  • Food Preferences / physiology*
  • Humans
  • Inpatients
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Middle Aged
  • Peptides / blood*
  • Sex Factors
  • Sleep Deprivation / physiopathology

Substances

  • Blood Proteins
  • Dietary Carbohydrates
  • Dietary Fats
  • Enho protein, human
  • Intercellular Signaling Peptides and Proteins
  • Peptides