A "dial-a-receptor" dynamic combinatorial library

Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12368-72. doi: 10.1002/anie.201305744. Epub 2013 Oct 2.


Making receptors to order: A small dynamic combinatorial library (DCL), formed from two dithiols in water, provides a continuous range of six receptors of different sizes. The majority of the 30 tested amines and ammonium ions amplified receptors from this library, thus spanning the complete receptor-size range and showing that this DCL provides a generic platform for the development of receptors for this important class of compounds.

Keywords: combinatorial chemistry; host-guest systems; molecular recognition; noncovalent interactions; supramolecular chemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Ammonium Compounds / chemistry*
  • Catenanes / chemistry
  • Combinatorial Chemistry Techniques*
  • Ions / chemistry
  • Kinetics
  • Macrocyclic Compounds / chemical synthesis
  • Macrocyclic Compounds / chemistry
  • Sulfhydryl Compounds / chemistry
  • Water / chemistry


  • Amines
  • Ammonium Compounds
  • Catenanes
  • Ions
  • Macrocyclic Compounds
  • Sulfhydryl Compounds
  • Water