A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection

World J Gastroenterol. 2013 Oct 7;19(37):6299-303. doi: 10.3748/wjg.v19.i37.6299.


Plasmablastic lymphoma (PBL) is a very rare B-cell lymphoproliferative disorder was with an aggressive clinical behavior that recently characterized by the World Health Organization. Although PBL is most commonly observed in the oral cavity of human immunodeficiency virus (HIV)-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. Epstein-Barr virus (EBV) may be closely related the pathogenesis of PBL. PBL shows different clinicopathological characteristics between HIV-positive and -negative patients. Here, we report a case of PBL of the liver in a 79-year-old HIV-negative male. The patient died approximately 1.5 mo after examination and autopsy showed that the main lesion was a very large liver mass. Histopathological examination of the excised lesion showed large-cell lymphoma with plasmacytic differentiation diffusely infiltrating the liver and involving the surrounding organs. The neoplastic cells were diffusely positive for CD30, EBV, Bob-1, and CD38. The autopsy findings suggested a diagnosis of PBL. To our knowledge, the present case appears to be the first report of PBL with initial presentation of the liver in a patient without HIV infection.

Keywords: Human immunodeficiency virus-negative; Immunohistochemistry; Normal liver; Pathogenesis; Plasmablastic lymphoma.

Publication types

  • Case Reports

MeSH terms

  • ADP-ribosyl Cyclase 1 / analysis
  • Aged
  • Autopsy
  • Biomarkers, Tumor / analysis
  • Fatal Outcome
  • Herpesvirus 4, Human / isolation & purification
  • Humans
  • Immunohistochemistry
  • Ki-1 Antigen / analysis
  • Liver Neoplasms / chemistry
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / therapy
  • Liver Neoplasms / virology
  • Lymphoma, Large B-Cell, Diffuse / chemistry
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Lymphoma, Large B-Cell, Diffuse / therapy
  • Lymphoma, Large B-Cell, Diffuse / virology
  • Male
  • Membrane Glycoproteins / analysis
  • Palliative Care
  • Tomography, X-Ray Computed
  • Trans-Activators / analysis


  • Biomarkers, Tumor
  • Ki-1 Antigen
  • Membrane Glycoproteins
  • POU2AF1 protein, human
  • Trans-Activators
  • CD38 protein, human
  • ADP-ribosyl Cyclase 1