Clinical experimentation with aerosol antibiotics: current and future methods of administration

Drug Des Devel Ther. 2013 Oct 2;7:1115-34. doi: 10.2147/DDDT.S51303. eCollection 2013.


Currently almost all antibiotics are administered by the intravenous route. Since several systems and situations require more efficient methods of administration, investigation and experimentation in drug design has produced local treatment modalities. Administration of antibiotics in aerosol form is one of the treatment methods of increasing interest. As the field of drug nanotechnology grows, new molecules have been produced and combined with aerosol production systems. In the current review, we discuss the efficiency of aerosol antibiotic studies along with aerosol production systems. The different parts of the aerosol antibiotic methodology are presented. Additionally, information regarding the drug molecules used is presented and future applications of this method are discussed.

Keywords: aerosol; antibiotics; nebulizers.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Aerosols
  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Drug Design*
  • Humans
  • Nanoparticles*
  • Nanotechnology / methods
  • Nebulizers and Vaporizers


  • Aerosols
  • Anti-Bacterial Agents