A new MspI restriction fragment length polymorphism in the hemophilia B locus

Hum Genet. 1985;71(1):79-81. doi: 10.1007/BF00295673.


Using a partial cDNA probe for human coagulation factor IX, we have detected a new restriction fragment length polymorphism in human DNA digested with MspI. The frequency of the minor allele is 0.20 +/- 0.05 and average heterozygosity is about 0.32. The MspI RFLP is in strong linkage disequilibrium with the TaqI RFLP previously described, but should nevertheless be useful in segregation analysis in case of homozygosity for the TaqI minor allele.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • DNA / genetics
  • DNA Restriction Enzymes*
  • Deoxyribonuclease HpaII
  • Female
  • Gene Frequency
  • Genetic Linkage
  • Genetic Markers
  • Hemophilia B / genetics*
  • Humans
  • Male
  • Nucleic Acid Hybridization
  • Pedigree
  • Polymorphism, Genetic*


  • Genetic Markers
  • DNA
  • DNA Restriction Enzymes
  • Deoxyribonuclease HpaII