Respiratory manifestations of gastroesophageal reflux disease

Ann N Y Acad Sci. 2013 Oct;1300:43-52. doi: 10.1111/nyas.12231.


Gastroesophageal reflux disease (GERD) is highly associated with a range of respiratory symptoms, arising from a variety of etiologies. The following commentaries on respiratory manifestations of GERD address evidence for a role of a vagally mediated bronchoconstriction reflex in the development of asthma; the direct effects of airway obstruction on lower esophageal sphincter (LES) pressure and reflux episodes; the mechanisms by which reflux may play roles in chronic cough and airway stenosis; the limited efficacy of laparoscopic antireflux surgery (LARS) in improving GERD-related respiratory symptoms; the search for a marker for microaspiration and reflux-induced airway disease; and the potential of proton pump inhibitor (PPI) treatment for patients presenting with asthma and GERD.

Keywords: GERD; asthma; bronchoconstriction; extra-esophageal reflux.

Publication types

  • Review

MeSH terms

  • Asthma / etiology*
  • Asthma / physiopathology
  • Bronchoconstriction / physiology*
  • Cough / etiology*
  • Cough / physiopathology
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / physiopathology
  • Humans